Exploring New Treatment Options for Severe Sickle Cell Disorder: The REDRESS study

Living with Sickle Cell Disorder (SCD) often means managing intense pain, regular transfusions, and a range of medications. For those hoping for a more lasting solution, the REDRESS trial offers an exciting new avenue of research. This nationwide study is investigating whether a type of stem cell transplant from family members who are half-matches (known as “haplo-donors”) can offer a safe, effective treatment for severe cases of SCD. Here’s a closer look at the trial, its progress so far, and how you can get involved.

What is the REDRESS study?

REDRESS is a groundbreaking trial that aims to see if stem cell transplants from half-matched family donors can provide a cure for those with severe SCD. Previous research has shown that transplant is curative of SCD in patients that have a donor who is a full match, usually a sibling. However, most (approximately 70%) living with SCD do not have a fully matched sibling available as a donor. Further research has shown that stem cell transplant from half-matched family donors has similar potential to cure severe SCD and is used routinely in England in children up to age 18. We do not yet know for certain if stem transplant using half-matched family donors offers the same potential as a treatment in adults, and this is the reason for this research.

A haplo-donor can be a sibling or half-sibling, parents, grown-up children, aunts, uncles, or even cousins. In REDRESS, “severe” SCD is not related to being a SS or SC type, but includes people who have frequent pain crises, need regular blood transfusions, or are on medications like hydroxycarbamide.  The study seeks to recruit around 120 volunteers across various hospitals in the UK to evaluate the safety and effectiveness of this transplant approach in adults.

Progress So Far

Since our successful launch event in May 2023, the REDRESS team has opened 10 centres across the country in major cities, including London, Birmingham, Manchester, Sheffield, and Bristol. While we’re pleased to have reached this milestone, we’re actively looking for more volunteers to participate in the trial. Whether you’re based near one of our current centres or at another hospital, there may be opportunities to get involved.

Building Stronger Connections with the Community

A vital part of the REDRESS study is connecting with patients, families, and communities impacted by sickle cell. We’re actively working with the Sickle Cell Society and regularly participate in events organised by the National Institute for Health Research (NIHR) and other patient groups. Our team is also keen to attend and speak at local events. We believe that engaging directly with those who are affected by SCD helps us shape our research to better meet patient needs and expectations.

How You Can Help or Get Involved

If you or someone you know might be interested in learning more about REDRESS or participating in our research, we would love to hear from you. Please visit our website or contact the research team at redress@kcl.ac.uk or on 020 7848 0360. We welcome any questions, and we’re especially interested in hearing different perspectives from the community. Your insights could play a valuable role in shaping the future of this important research.

The REDRESS trial is more than just a study – it’s a community-driven effort to bring meaningful improvements to the lives of people with severe sickle cell disorder. Together, we can explore new treatments and move one step closer to better options for everyone affected by SCD.

A guest Blog Post from Daryl Hagan,
Senior Trial Manager, King’s College Clinical Trial Unit.